Enhancing immunogenicity by limiting susceptibility to lysosomal proteolysis
نویسندگان
چکیده
منابع مشابه
Enhancing immunogenicity by limiting susceptibility to lysosomal proteolysis
T cells recognize protein antigens as short peptides processed and displayed by antigen-presenting cells. However, the mechanism of peptide selection is incompletely understood, and, consequently, the differences in the immunogenicity of protein antigens remain largely unpredictable and difficult to manipulate. In this paper we show that the susceptibility of protein antigens to lysosomal prote...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2006
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20052442